Preheat the oven to 400°F. Line a rimmed baking sheet with parchment paper. Set aside.
In a medium bowl, combine the 1/2 cup seasoned bread crumbs*, 1/2 cup Parmesan cheese, 1/2 teaspoon garlic powder, 1/2 teaspoon onion powder, 1/2 teaspoon coarse Kosher salt and 1/2 teaspoon ground black pepper. When mixed, drizzle in the melted 3 tablespoons butter. It will resemble wet sand.
Place the 4 large tilapia filets onto the prepared baking sheet. Spoon the breadcrumb mixture over the top of each evenly.
Bake the filets for 17-20 minutes. At the very end, turn on the broiler for 1 minute just to get a little browning. Watch carefully to not burn!
Remove and serve with fresh lemon or sauce of your choice.
If you've tried this recipe, come back and let us know how it was in the comments or ratings.
Notes
**You can use plain breadcrumbs or combine 2 teaspoons of Italian seasoning with plain breadcrumbs to season them. You can also panko or even cracker crumbs like Ritz or saltine. If you do use a salted cracker, omit additional Kosher salt.